Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses

Author:

Khawaja Anthony P.1,Cooke Bailey Jessica N.2,Kang Jae Hee3,Allingham R. Rand4,Hauser Michael A.5,Brilliant Murray6,Budenz Donald L.7,Christen William G.8,Fingert John9,Gaasterland Douglas10,Gaasterland Terry11,Kraft Peter12,Lee Richard K.13,Lichter Paul R.14,Liu Yutao15,Medeiros Felipe16,Moroi Syoko E.14,Richards Julia E.17,Realini Tony18,Ritch Robert19,Schuman Joel S.20,Scott William K.21,Singh Kuldev22,Sit Arthur J.23,Vollrath Douglas24,Wollstein Gadi25,Zack Donald J.26,Zhang Kang16,Pericak-Vance Margaret21,Weinreb Robert N.16,Haines Jonathan L.2,Pasquale Louis R.27,Wiggs Janey L.28

Affiliation:

1. National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust, and University College London (UCL) Institute of Ophthalmology, London, United Kingdom

2. Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

3. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

4. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States

5. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States 5Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States

6. Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States

7. Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, United States

8. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

9. Department of Ophthalmology, University of Iowa, College of Medicine, Iowa City, Iowa, United States 10Stephen A. Wynn Institute for Vision Research, Iowa City, Iowa, United States

10. The Emmes Corporation, Rockville, Maryland, United States

11. Scripps Genome Center, University of California at San Diego, San Diego, California, United States

12. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States 14Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, United States

13. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States

14. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States

15. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, United States 18James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, United States

16. Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, San Diego, California, United States

17. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States 20Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States

18. Department of Ophthalmology, West Virginia University Eye Institute, Morgantown, West Virginia, United States

19. Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States

20. Department of Ophthalmology, New York University, New York, New York, United States

21. Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States

22. Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States

23. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States

24. Department of Genetics, Stanford University School of Medicine, Palo Alto, California, United States

25. Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

26. Wilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, Maryland, United States

27. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States 30Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States

28. Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

General Medicine

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