GSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3/MLKL-Mediated RGC Necroptosis After Ischemia/Reperfusion

Author:

Feng Yanlin1,Hu Chenyang1,Cui Kaixuan1,Fan Matthew2,Xiang Wu1,Ye Dan1,Shi Yuxun1,Ye Huiwen1,Bai Xue1,Wei Yantao1,Xu Yue1,Huang Jingjing1

Affiliation:

1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China

2. Yale College, Yale University, New Haven, Connecticut, United States

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

Cardiology and Cardiovascular Medicine

Reference50 articles.

1. Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway;Gao;Mol Vis,2014

2. Retinal ischemia: mechanisms of damage and potential therapeutic strategies;Osborne;Prog Retin Eye Res,2004

3. Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury;Qin;Cell Death Dis,2022

4. Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage;Dvoriantchikova;Exp Eye Res,2014

5. Necroptosis;Linkermann;N Engl J Med,2014

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