1. Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan
2. Biological Information Research Center, National Institutes of Advanced Industrial Science and Technology, Kohtoh-ku, Tokyo 135-0064, Japan
3. Department of Internal Medicine-MMG, University of Michigan Medical School, Ann Arbor, MI 48109
4. Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan