Affiliation:
1. Division of Rheumatology, Immunology, and Allergy, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115
Abstract
The accumulation of stalled translation preinitiation complexes (PICs) mediates the condensation of stress granules (SGs). Interactions between prion-related domains and intrinsically disordered protein regions found in SG-nucleating proteins promote the condensation of ribonucleoproteins into SGs. We propose that PIC components, especially 40S ribosomes and mRNA, recruit nucleators that trigger SG condensation. With resolution of stress, translation reinitiation reverses this process and SGs disassemble. By cooperatively modulating the assembly and disassembly of SGs, ribonucleoprotein condensation can influence the survival and recovery of cells exposed to unfavorable environmental conditions.
Funder
National Institutes of Health
Publisher
Rockefeller University Press
Reference115 articles.
1. Stressful initiations;Anderson;J. Cell Sci.,2002
2. RNA granules;Anderson;J. Cell Biol.,2006
3. Stress granules;Anderson;Curr. Biol.,2009
4. Stress granules, P-bodies and cancer;Anderson;Biochim. Biophys. Acta.,2014
5. Compositional control of phase-separated cellular bodies;Banani;Cell.,2016
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