Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins

Author:

Papp S.1,Dziak E.1,Michalak M.2,Opas M.1

Affiliation:

1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8

2. Canadian Institutes of Health Research, Membrane Protein Research Group, and the Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

Abstract

The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca2+-handling proteins, namely the Ca2+-binding proteins, the Ca2+ pumps and the Ca2+ release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca2+ signals, Ca2+ homeostasis, and protein folding and quality control.

Publisher

Rockefeller University Press

Subject

Cell Biology

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