1. School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610‑000, Brazil
2. Quatro G P&D Ltda., Porto Alegre, Rio Grande do Sul 90619‑900, Brazil
3. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT 06520‑8063, USA