Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity

Author:

Zhang Yihan12,Black Katharine Elliot3,Phung Thien-Khoi N.4,Thundivalappil Sujatha Rajeev12,Lin Tian12,Wang Wei5,Xu Jie6,Zhang Cheng7,Hariri Lida P.38,Lapey Allen9,Li Hu7,Lerou Paul Hubert5,Ai Xingbin5,Que Jianwen101112,Park Jin-Ah4,Hurley Bryan P.12,Mou Hongmei12ORCID

Affiliation:

1. The Mucosal Immunology & Biology Research Center,

2. Department of Pediatrics, Harvard Medical School, and

3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, and

4. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts;

5. Division of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts;

6. Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School, Ann Arbor, Michigan;

7. Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota;

8. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;

9. Division of Pediatric Pulmonary Medicine, Massachusetts General Hospital for Children, Boston, Massachusetts;

10. Columbia Center for Human Development,

11. Division of Digestive and Liver Disease, Department of Medicine, and

12. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York

Funder

Job Research Foundation

Cystic Fibrosis Foundation Research Grant

Hood Child Health Research Award

Harvard Stem Cell Institute Seed Grant

Foundation for the National Institutes of Health

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

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