Analysis of Insulinoma-Associated Protein 1 Expression in Pituitary Neuroendocrine Tumors

Author:

Hirokawa Yu1,Inomoto Chie2,Oyama Kenichi3,Tahara Shigeyuki4,Y. Osamura Robert5,Shiomi Takayuki6,Matsuno Akira3

Affiliation:

1. Department of Neurosurgery, International University of Health and Welfare, Narita Hospital

2. Department of Pathology, School of Medicine, Tokai University

3. Department of Neurosurgery, International University of Health and Welfare, Mita Hospital

4. Department of Neurological Surgery, Nippon Medical School

5. Department of Diagnostic Pathology, Nippon Koukan Hospital

6. Graduate School of Medicine, International University of Health and Welfare

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference14 articles.

1. 1 WHO Classification of Tumours Editorial Board. Endocrine and Neuroendocrine tumours, vol. 8. 5th edn. (International Agency for Research on Cancer, Lyon, France, 2022) https://tumourclassification.iarc.who.int.

2. 2 Chandrasekaran, Kundhavai., Sundaram, Sandhya., Balasubramanian, Subalakshmi. (2023) INSM1 expression in neuroendocrine tumors in a tertiary care hospital. Journal of Cancer Research and Therapeutics doi: 10.4103/jcrt.jcrt_2329_22.

3. 3 Fujino, K., Yasufuku, K., Kudoh, S., Motooka, Y., Sato, Y., Wakimoto, J., et al. (2017) INSM1 is the best marker for the diagnosis of neuroendocrine tumors: Comparison with CGA, SYP and CD56. Int. J. Clin. Exp. Pathol. 10; 5393–5405.

4. 4 Goto, Y., De Silva, M. G., Toscani, A., Prabhakar, B. S., Notkins, A. L. and Lan, M. S. (1992) A novel human insulinoma-associated cDNA, IA-1, encodes a protein with “zinc-finger” DNA-binding motifs. J. Biol. Chem. 267; 15252–15257.

5. 5 Kriegsmann, K., Zgorzelski, C., Kazdal, D., Cremer, M., Muley, T., Winter, H., et al. (2020) Insulinoma-associated protein 1 (INSM1) in thoracic tumors is less sensitive but more specific compared with synaptophysin, chromogranin A, and CD56. Appl. Immunohistochem. Mol. Morphol. 28; 237–242.

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