EXPERIMENTAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF OXYMETHYLURACIL IN COMBINATION WITH KNOWN MEDICINES (MEXIDOL, TONAROL, ACETYLCYSTEINE)-Reference-Cited by-同舟云学术

EXPERIMENTAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF OXYMETHYLURACIL IN COMBINATION WITH KNOWN MEDICINES (MEXIDOL, TONAROL, ACETYLCYSTEINE)

Published:2021-01-05 Issue:6 Volume: Page:14-20
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Repina Е. F.¹,Karimov D. O.¹,Timasheva G. V.¹,Khusnutdinova N. Yu.¹,Musina L. A.²,Gimadieva A. R.³,Baigildin S. S.⁴,Smolyankin D. A.¹,Valova Ya. V.¹

Affiliation:

1. Ufa Institute of Occupational Health and Human Ecology

2. All-Russian Centre of Eye and Plastic Surgery of the Russian Health Ministry

3. Ufa Institute of Chemistry UFIC RAS

4. Ufa Institute of Occupational Health and Human Ecology; Bashkir State University

Abstract

The article presents the results of morphological changes in the liver of rats after acute liver injury induced by carbon tetrachloride and prophylactic correction of injuries by combinations of oxymethyluracil with different types of medical products: «Mexidol», «Tonarol» and Acetylcysteine. The best corrective effect was established after applying a combination of oxymethyluracil with «Tonarol». Thus, according to the results obtained, the studied drugs combinations can be arranged in the following sequence in accordance with decreasing of hepatoprotective activity: OMU / «Tonarol» > OMU / Acetylcysteine> OMU / «Mexidol».

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

Reference17 articles.

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