Lipid profile and apolipoprotein A1 and B levels in women with pre- and postmenopausal breast cancer undergoing neoadjuvant therapy

Abstract

Breast cancer is associated with modifiable risk factors such as diet and obesity. In this sense, the circulating levels of apolipoproteins and lipoproteins such as LDL cholesterol or HDL cholesterol could be involved in tumor development and be modified by them. Also, the hormonal profile of the patients seems to be a decisive factor in the progression of the disease, as well as determining, to a certain extent, the presence of obesity in postmenopausal women. In this context, the purpose of this work has been to determine the levels of lipoproteins, specifically, LDL cholesterol and HDL cholesterol, using standard enzymatic colorimetric methods, as well as apolipoproteins ApoA1 and ApoB, using specific ELISA kits, in pre- and postmenopausal women with breast cancer treated or not with neoadjuvant chemotherapy in comparison with healthy pre- and postmenopausal women. The significant differences obtained between groups of patients studied at the levels of lipoproteins and apolipoproteins, lead us to conclude that the hormonal profile is decisive to regulate lipid metabolism and that it is possibly involved in the progression of the disease according to the administration or not of neoadjuvant chemotherapy, mainly in postmenopausal women.