Saliva – a new opportunity for fluid biopsy-Reference-Cited by-同舟云学术

Saliva – a new opportunity for fluid biopsy

Published:2022-10-27 Issue:1 Volume:61 Page:4-32
ISSN:1434-6621
Container-title:Clinical Chemistry and Laboratory Medicine (CCLM)
language:en
Short-container-title:

Author:

Huang Zhijie¹^ORCID,Yang Xiaoxia²,Huang Yisheng¹,Tang Zhengming¹,Chen Yuanxin¹,Liu Hongyu¹,Huang Mingshu¹,Qing Ling¹,Li Li¹,Wang Qin¹,Jie Zhuye³⁴⁵,Jin Xin³⁶,Jia Bo¹

Affiliation:

1. Department of Oral Surgery, Stomatological Hospital , Southern Medical University , Guangzhou , P.R. China

2. Department of Endodontics, Stomatological Hospital , Southern Medical University , Guangzhou , P.R. China

3. BGI Genomics, BGI-Shenzhen , Shenzhen , P.R. China

4. Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen , Shenzhen , P.R. China

5. Laboratory of Genomics and Molecular Biomedicine, Department of Biology , University of Copenhagen , Copenhagen , Denmark

6. School of Medicine , South China University of Technology , Guangzhou , P.R. China

Abstract

Abstract Saliva is a complex biological fluid with a variety of biomolecules, such as DNA, RNA, proteins, metabolites and microbiota, which can be used for the screening and diagnosis of many diseases. In addition, saliva has the characteristics of simple collection, non-invasive and convenient storage, which gives it the potential to replace blood as a new main body of fluid biopsy, and it is an excellent biological diagnostic fluid. This review integrates recent studies and summarizes the research contents of salivaomics and the research progress of saliva in early diagnosis of oral and systemic diseases. This review aims to explore the value and prospect of saliva diagnosis in clinical application.

Funder

Natural Science Foundation of Guangdong Province

Research and Cultivation Project of Stomatological Hospital, Southern Medical University

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Link

https://www.degruyter.com/document/doi/10.1515/cclm-2022-0793/pdf

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