Affiliation:
1. Department of Laboratory Medicine Center, Nanfang Hospital , Southern Medical University , Guangzhou , Guangdong , P. R. China
2. Department of Clinical Laboratory, Guangzhou Women & Children Medical Center , Guangzhou Medical University , Guangzhou , P. R. China
Abstract
Abstract
Cell senescence is a fundamental mechanism of aging and appears to play vital roles in the onset and prognosis of cardiovascular disease, fibrotic pulmonary disease, liver disease and tumor. Moreover, an increasing body of evidence shows that cell senescence plays an indispensable role in the formation and development of atherosclerosis. Multiple senescent cell types are associated with atherosclerosis, senescent human vascular endothelial cells participated in atherosclerosis via regulating the level of endothelin-1 (ET-1), nitric oxide (NO), angiotensin II and monocyte chemoattractant protein-1 (MCP-1), senescent human vascular smooth muscle cells-mediated plaque instability and vascular calcification via regulating the expression level of BMP-2, OPN, Runx-2 and inflammatory molecules, and senescent macrophages impaired cholesterol efflux and promoted the development of senescent-related cardiovascular diseases. This review summarizes the characteristics of cell senescence and updates the molecular mechanisms underlying cell senescence. Moreover, we also discuss the recent advances on the molecular mechanisms that can potentially regulate the development and progression of atherosclerosis.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Natural Science Foundation of Guangdong province--Outstanding Youth Foundation
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
Cited by
41 articles.
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