Substances of abuse and their effect on SAR-CoV-2 pathogenesis
Author:
Antwi Ivy1, Watkins Destiny1, Pedawi Alahn1, Ghrayeb Atheel1, Van de Vuurst Christine1, Cory Theodore J.1ORCID
Affiliation:
1. Department of Clinical Pharmacy, College of Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA
Abstract
Abstract
Following the emergence of SARS-CoV-2, various reports suggest that there has been a significant increase in substance abuse due to social distancing and related issues. Several reports have suggested the impact of chronic substance use on individuals’ physiological and psychological health. Therefore, there is a need to know the impact of SARS-CoV-2 on persons with substance use disorders. Individuals with substance use disorders are the most vulnerable groups and are at a high risk of SARS-CoV-2 infection due to their already existing health issues associated with substance use. This review discusses some of the molecular and systemic/organic effects chronic substance use such as alcohol, nicotine, marijuana (cannabis), opioids, methamphetamine, and cocaine have on SARS-CoV-2 infectivity and its potential cause for worsened disease outcomes in persons with substance use disorder. This will provide healthcare providers, public health policies, and researchers with the needed knowledge to address some of the many challenges faced during the Covid-19 pandemic to facilitate treatment strategies for persons with substance use disorders.
Funder
National Institutes of Health
Publisher
Walter de Gruyter GmbH
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