Synthesis, characterization, and antibacterial activity of a new poly azo compound containing <i>N</i>-arylsuccinimid and dibenzobarrelene moieties-Reference-Cited by-同舟云学术

Synthesis, characterization, and antibacterial activity of a new poly azo compound containing N-arylsuccinimid and dibenzobarrelene moieties

Published:2023-01-01 Issue:1 Volume:29 Page:
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:en
Short-container-title:

Author:

Salamou Njoya Abdou¹^ORCID,Jean-de-Dieu Tamokou²^ORCID,Emmanuel Sopbué Fondjo¹^ORCID,Germaine Matsuete Takongmo²,Gabin Bitchagno Mbahbou T.¹,Simon Peter F. W.³^ORCID,Tsopmo Apollinaire⁴,Jules-Roger Kuiate²^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Laboratory of Applied Synthetic Organic Chemistry, University of Dschang , P.O. Box 67 Dschang , Republic of Cameroon

2. Department of Biochemistry, Faculty of Science, Research Unit of Microbiology and Antimicrobial Substances, University of Dschang , PO Box 067 Dschang , Republic of Cameroon

3. Polymer Chemistry Laboratory, Faculty of Life Sciences, Rhein-Waal University of Applied Sciences, Marie-Curie Strasse 1 , D-47533 Kleve , Germany

4. Department of Chemistry, Carleton University , 1125 Colonel By Drive, K1S 5B6 , Ottawa , Canada

Abstract

Abstract The present work describes the synthesis, characterization, and evaluation of the antibacterial activity of a new poly azo compound resulting from the coupling of a previously reported N-arylsuccinimid precursor 5 with the diazonium ion of aniline. This azo compound was characterized using its physical, elemental, and 1D and 2D spectroscopic data. The novel azo compound 7 (minimum inhibitory concentration [MIC] = 16–32 μg/mL) showed higher antibacterial activity than its precursor 5 (MIC = 32–64 μg/mL), although it was low compared to the reference drug ciprofloxacin (MIC = 0.5–4 μg/mL).

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2022-0157/pdf

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