PD98059 protects SH-SY5Y cells against oxidative stress in oxygen–glucose deprivation/reperfusion-Reference-Cited by-同舟云学术

PD98059 protects SH-SY5Y cells against oxidative stress in oxygen–glucose deprivation/reperfusion

Published:2023-01-01 Issue:1 Volume:14 Page:
ISSN:2081-6936
Container-title:Translational Neuroscience
language:en
Short-container-title:

Author:

Zhuge Xiang-Zhen¹,Hu Wan-Xiang¹,Liu Yu-Mei²,Jiang Chang-Yue³,Zhang Xiao-Hua¹,Chen Meng-Hua⁴,Xie Lu¹

Affiliation:

1. Department of Physiology, Pre-Clinical Science, Guangxi Medical University , 22 Shuangyong Road , Nanning , 350001, Guangxi , China

2. Shenzhen Bay Laboratory Neuropathy Institute of China , Shenzhen , 518107, Guangdong , China

3. Department of Pharmacy, HIV/AIDS Clinical Treatment Center of Guangxi (Nanning) and The Fourth People’s Hospital of Nanning , Nanning , 530000 , China

4. Institute of Cardiovascular Diseases, The Second Hospital Affiliated to Guangxi Medical University , Nanning , 530000, Guangxi , China

Abstract

Abstract Mitochondria play a key role in the cerebral ischemia-reperfusion injury. Although the extracellular signal-regulated kinase 1/2 inhibitor PD98059 (PD) is a selective and reversible flavonoid that can protect the mitochondria in a rat model of cardiac arrest/cardiopulmonary resuscitation, its role requires further confirmation. In this study, we investigated whether PD could maintain mitochondrial homeostasis and decrease reactive oxygen species (ROS) production in neuroblastoma (SH-SY5Y) cells exposed to oxygen–glucose deprivation/reperfusion (OGD/R). PD improved the mitochondrial morphology and function, reversed the increase in ROS production and cell apoptosis, and reduced total-superoxide dismutase and Mn-superoxide dismutase activities induced by OGD/R. PD decreases ROS production and improves mitochondrial morphology and function, protecting SH-SY5Y cells against OGD/R-induced injury.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0300/pdf

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