Effects of gut microbiota and probiotics on Alzheimer’s disease

Author:

Guo Libing1,Xu Jiaxin2,Du Yunhua1,Wu Weibo1,Nie Wenjing1,Zhang Dongliang1,Luo Yuling1,Lu Huixian1,Lei Ming2,Xiao Songhua23,Liu Jun23

Affiliation:

1. Department of Neurology, Foshan Third People’s Hospital , No. 102 Jinlan South Road , Foshan , Guangdong , China

2. Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107 Yanjiang West Road, Guangzhou , Guangdong , China

3. Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University , Guangzhou , China

Abstract

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health. The failure in drug discovery over the past decades has stressed the urgency and importance of seeking new perspectives. Recently, gut microbiome (GM), with the ability to communicate with the brain bidirectionally through the microbiome–gut–brain axis, has attracted much attention in AD-related studies, owing to their strong associations with amyloids, systematic and focal inflammation, impairment of vascular homeostasis and gut barrier, mitochondrial dysfunction, etc., making the regulation of GM, specifically supplementation of probiotics a promising candidate for AD treatment. This article aims to review the leading-edge knowledge concerning potential roles of GM in AD pathogenesis and of probiotics in its treatment and prevention.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

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