Comprehensive behavioral study of C57BL/6.KOR-ApoE<sup>shl</sup> mice-Reference-Cited by-同舟云学术

Comprehensive behavioral study of C57BL/6.KOR-ApoE^shl mice

Published:2023-01-01 Issue:1 Volume:14 Page:
ISSN:2081-6936
Container-title:Translational Neuroscience
language:en
Short-container-title:

Author:

Ueno Hiroshi¹,Takahashi Yu²,Murakami Shinji²,Wani Kenta²,Miyazaki Tetsuji²,Matsumoto Yosuke³,Okamoto Motoi⁴,Ishihara Takeshi²

Affiliation:

1. Department of Medical Technology, Kawasaki University of Medical Welfare , 288, Matsushima, Kurashiki , Okayama , 701-0193 , Japan

2. Department of Psychiatry, Kawasaki Medical School , Kurashiki , 701-0192 , Japan

3. Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University , Okayama , 700-8558 , Japan

4. Department of Medical Technology, Graduate School of Health Sciences, Okayama University , Okayama , 700-8558 , Japan

Abstract

Abstract Background Apolipoprotein E (ApoE) is associated with Alzheimer’s disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoeshl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoeshl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoeshl mice. Results Apoeshl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoeshl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test. Conclusion Our findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0284/pdf

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