Vascular endothelial growth factor (VEGF)-C and its receptors, soluble VEGFR-2 and VEGFR-3, in polycystic ovary syndrome-Reference-Cited by-同舟云学术

Vascular endothelial growth factor (VEGF)-C and its receptors, soluble VEGFR-2 and VEGFR-3, in polycystic ovary syndrome

Published:2024-01-30 Issue:0 Volume:0 Page:
ISSN:1303-829X
Container-title:Turkish Journal of Biochemistry
language:en
Short-container-title:

Author:

Ozen Fatma Zeynep¹^ORCID,Kaya-Sezginer Ecem²^ORCID,Kırlangıc Omer Faruk³⁴^ORCID,Tekeli Taskomur Aysun⁵^ORCID,Aktan Fugen²^ORCID,Kaplan Gul²^ORCID,Ozgurtas Taner⁶^ORCID

Affiliation:

1. Department of Pathology , Faculty of Medicine, Amasya University , Amasya , Türkiye

2. Department of Biochemistry , Faculty of Pharmacy, Ankara University , Ankara , Türkiye

3. Vocational School of Health , Ankara University , Ankara , Türkiye

4. Department of Medical Biochemistry , Faculty of Medicine , Gazi University , Ankara , Türkiye

5. Department of Obstetrics and Gynecology , Faculty of Medicine, Amasya University , Amasya , Türkiye

6. Department of Medical Biochemistry , Gulhane Faculty of Medicine, University of Health Sciences , Ankara , Türkiye

Abstract

Abstract Objectives Angiogenesis is involved in polycystic ovary syndrome (PCOS) progression. Vascular endothelial growth factor C (VEGF-C) and its receptors are key angiogenic markers. The main objective of this study was to investigate the serum levels of VEGF-C and its receptors, soluble VEGF receptor 2 (sVEGFR-2) and VEGFR-3, in patients with PCOS and healthy controls and determine the link between serum levels of these VEGF-related proteins and the biochemical and hormonal data of patients with PCOS. Methods Thirty-six women with PCOS and 30 controls were included in this study. The measurement of VEGF-C, sVEGFR-2, and VEGFR-3 levels in serum and routine biochemical and hormone analysis were performed. Results In the PCOS group, significantly higher serum sVEGFR-2 levels and no significant differences in serum VEGF-C and VEGFR-3 were observed compared to the controls. Serum sVEGFR-2 levels exhibited positive associations with VEGF-C, VEGFR-3, total cholesterol, and anti-müllerian hormone (AMH) in women with PCOS. Moreover, a positive correlation between serum VEGF-C and VEGFR-3 concentrations was detected in patients with PCOS. The cutoff value of serum sVEGFR-2 was 4.24 ng/mL (sensitivity 68 %, specificity 64 %) to distinguish PCOS. Conclusions Despite unaltered levels of serum VEGF-C and VEGFR-3, there was an association between circulating levels of sVEGFR-2 and these VEGF-related proteins. sVEGFR-2 could be a promising diagnostic biomarker for PCOS. Regarding the significant correlation between sVEGFR-2 and AMH, sVEGFR-2 could have an impact on the hormonal elements of PCOS. Further studies are warranted to fully understand the function of VEGF-C and its receptors in PCOS.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/tjb-2023-0202/pdf

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