Lignan glycosides from the stems of Viburnum melanocarpum and their α-glucosidase inhibitory activity

Author:

Zhao Chunchao1,Chen Jia23,Shao Jianhua4,Shen Jie23,Gu Wenyan3,Zhang Xiaohui3,Sha Yusi2

Affiliation:

1. College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, P.R. China, Phone: +86-514-87991556

2. College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, P.R. China

3. Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou 225009, P.R. China

4. Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou 225009, P.R. China, Phone: +86-514-87979054

Abstract

AbstractTwo new lignan glycosides (1, 2) and four known lignan glycosides (36) have been isolated from the ethanolic extract of the stems of Viburnum melanocarpum through repeated column chromatography. Their structures including absolute configurations were confirmed by spectroscopic data [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectra (HRESIMS), optical rotatory dispersion (ORD) and circular dichroism (CD)] and chemical methods. Additionally, the α-glucosidase inhibitory activity of these compounds was tested in vitro. Compound 1 exhibited the strongest inhibitory activity against α-glucosidase with a half-maximal inhibitory concentration (IC50) value of 10.3 μM.

Publisher

Walter de Gruyter GmbH

Subject

Biomaterials

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