Author:
Amin Ehsan,Dubey Badri Nath,Zhang Si-Cai,Gremer Lothar,Dvorsky Radovan,Moll Jens M.,Taha Mohamed S.,Nagel-Steger Luitgard,Piekorz Roland P.,Somlyo Avril V.,Ahmadian Mohammad R.
Abstract
Abstract
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and adhesion plaques as well as in the regulation of transcription factors. Thus, ROCKI/II activity regulates cellular contraction, motility, morphology, polarity, cell division, and gene expression. Emerging evidence suggests that dysregulation of the Rho-ROCK pathways at different stages is linked to cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK activity, thereby orchestrating a concerted functional response.
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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