Relationship of thrombospondin-1 and thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients

Author:

Dogan Serdar1ORCID,Okuyan Hamza Malik23ORCID,Bal Tayibe45ORCID,Çabalak Mehmet5ORCID,Begen Mehmet A.6ORCID

Affiliation:

1. Department of Medical Biochemistry , Faculty of Medicine, Hatay Mustafa Kemal University, Hatay , Türkiye

2. Biomedical Technologies Application and Research Center, Sakarya University of Applied Sciences, Sakarya , Türkiye

3. Department of Physiotherapy and Rehabilitation , Faculty of Health Sciences, Sakarya University of Applied Sciences, Sakarya , Türkiye

4. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bolu Abant Izzet Baysal University , Bolu , Türkiye

5. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hatay Mustafa Kemal University , Hatay , Türkiye

6. Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Ivey Business School, University of Western Ontario, London , ON , Canada

Abstract

Abstract Objectives Roles of thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) in tissue repair and inflammation are well-documented, but the association of their serum expressions with the pathogenesis of COVID-19 remains unclear. We investigate the roles of TSP-1 and TSP-2 in COVID-19. Methods 106 SARS-CoV-2 infected patients and 23 healthy people were enrolled in our study. COVID-19 patients were divided into two groups as non-severe and severe. TSP-1 and TSP-2 concentrations were measured with an enzyme-linked Immunosorbent Assay, and blood markers were analyzed with routine laboratory techniques. Results COVID-19 patients had significantly higher TSP-1 and TSP-2 levels than healthy controls. TSP-1 and TSP-2 positively correlated with inflammatory markers, including ESR, CRP, PCT, ferritin, and biochemical parameters such as ALT, AST, BUN, CK, and LDH. In addition, TSP-1 and TSP-2 were negatively correlated with hematological markers such as LYM, EOS, and HGB. Receiver operating characteristic analyses revealed that COVID-19 may be predicted with TSP-1 levels over 189.94 ng/mL and TSP-2 levels higher than 0.70 ng/mL. Conclusions Our analysis suggests that TSP-1 and TSP-2 expressions at the systemic level may have clinical importance for COVID-19.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry

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