The effect of maternal diabetes on the expression of gamma-aminobutyric acid and metabotropic glutamate receptors in male newborn rats’ inferior colliculi

Author:

Ghenaatgar-Kasbi Maryam1ORCID,Rezaei Mohammad2ORCID,Moharreri Payam1ORCID,Heidarian Miri Hamid3ORCID,Sazegar Ghasem1ORCID,Haghir Hossein14ORCID

Affiliation:

1. Department of Anatomy and Cell Biology , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran

2. Department of Physiology , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran

3. Social Determinants of Health Research Center, Mashhad University of Medical Sciences , Mashhad , Iran

4. Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran

Abstract

Abstract Objectives Few studies have examined the molecular alterations in the auditory pathway of infants of diabetic mothers, notwithstanding the fact that maternal diabetes may have an impact on the development of the neonatal peripheral and central nervous systems. Male newborn rats were studied to determine how maternal diabetes affected the expression of gamma-aminobutyric acid (GABAAα1 and GABAB1) and metabotropic glutamate (mGlu2) receptors in the inferior colliculus (IC) in this research. Methods Female rats were given a single intraperitoneal injection of streptozotocin (STZ) at a 65 mg/kg dose to develop a model of diabetic mothers. The study population was split into sham, diabetes without treatment, and diabetes with insulin groups. Their male neonatal rats were anesthetized on P0, P7, and P14 after mating and delivery. The receptors’ distribution pattern was studied using immunohistochemistry (IHC). Results Pairwise comparison in the groups revealed that the GABA receptors (Aα1 and B1) were significantly downregulated in the diabetes without treatment group (p<0.001). Furthermore, pairwise comparison in the groups indicated significant mGlu2 upregulation in the diabetes without treatment group (p<0.001). Regarding the concentration of all receptors, there was no discernible distinction between the diabetes with insulin and sham groups. Conclusions This investigation showed that the concentration of GABAAα1 and GABAB1 receptors decreased significantly over time, whereas the concentration of mGlu2 receptors increased significantly over time in male neonatal rats born to streptozotocin-induced diabetic mothers.

Funder

Mashhad University of Medical Sciences

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

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1. The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19;International Journal of Molecular Sciences;2024-09-05

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