Minimally invasive in situ bioprinting using tube-based material transfer

Author:

Tomooka Yukiko1,Spothelfer Dominic1,Puiggali-Jou Anna2,Tourbier Céline34,Tankus Esma Bahar34,Thieringer Florian M.34,Cattin Philippe C.5,Rauter Georg1,Eugster Manuela1

Affiliation:

1. BIROMED-Lab, Department of Biomedical Engineering , University of Basel , Basel , Switzerland

2. Tissue Engineering and Biofabrication Lab, Department of Health Science and Technology , ETH Zürich , Zürich , Switzerland

3. Clinic of Oral and Cranio-Maxillofacial Surgery , University Hospital Basel , Basel , Switzerland

4. Swiss MAM Research Group, Department of Biomedical Engineering , University of Basel , Basel , Switzerland

5. CIAN, Department of Biomedical Engineering , University of Basel , Basel , Switzerland

Abstract

Abstract Minimally invasive in situ bioprinting can potentially enhance the advantages of bioprinting, allowing the surrounding healthy tissue to be maximally preserved. However, the requirements for such a device are manifold and challenging to fulfill. We present an experimental bioprinting platform consisting of an extrusion system based on a tube mounted between an extrusion syringe and a dispensing nozzle. We investigated the influence of material transfer through a tube on the printing outcome. The results showed that it is feasible to form a continuous filament and print 3-dimensional structures using the developed platform.

Publisher

Walter de Gruyter GmbH

Subject

Electrical and Electronic Engineering,Computer Science Applications,Control and Systems Engineering

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