A switching lung mechanics model for detection of expiratory flow limitation-Reference-Cited by-同舟云学术

A switching lung mechanics model for detection of expiratory flow limitation

Published:2024-05-01 Issue:5 Volume:72 Page:417-428
ISSN:0178-2312
Container-title:at - Automatisierungstechnik
language:en
Short-container-title:

Author:

Hennigs Carlotta¹^ORCID,Bilda Franziska¹^ORCID,Graßhoff Jan²^ORCID,Walterspacher Stephan³^ORCID,Rostalski Philipp¹²^ORCID

Affiliation:

1. 9191 Institute of Electrical Engineering in Medicine, Universität zu Lübeck , Luebeck , Germany

2. Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering , Luebeck , Germany

3. Medical Clinic – Dept of Pneumology, Klinikum Konstanz, Germany and Faculty of Health/School of Medicine , Witten/Herdecke University , Witten , Germany

Abstract

Abstract Expiratory flow limitation (EFL) is an often unrecognized clinical condition with a multitude of negative implications. A mathematical EFL model is proposed to detect flow limitations automatically. The EFL model is a switching one-compartment lung mechanics model with a volume-dependent airway resistance to simulate the dynamic behavior during expiration. The EFL detection is based on a breath-by-breath model parameter identification and validated on clinical data of mechanically ventilated patients. In the severe flow limitation group 93.9 % ± 5 % and in the no limitation group 10.2 % ± 13.7 % of the breaths are detected as EFL. Based on the high detection rate of EFL, these results support the usefulness of the EFL detection. It is a first step toward an automated detection of EFL in clinical applications and may help to reduce underdiagnosis of EFL.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/auto-2023-0206/pdf

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