Modulatory role of prolactin in type 1 diabetes-Reference-Cited by-全球学者库

Modulatory role of prolactin in type 1 diabetes

Published:2022-07-19 Issue:1 Volume:44 Page:79-88
ISSN:1868-1891
Container-title:Hormone Molecular Biology and Clinical Investigation
language:en
Short-container-title:

Author:

Ramos-Martínez Edgar¹^ORCID,Ramos-Martínez Ivan²,Valencia Jorge³,Ramos-Martínez Juan Carlos⁴,Hernández-Zimbrón Luis⁵,Rico-Luna Anaiza¹,Pérez-Campos Eduardo⁶,Pérez-Campos Mayoral Laura⁷,Cerbón Marco⁸

Affiliation:

1. Facultad de Química , Universidad Nacional Autónoma de México , Ciudad de México , México

2. Departamento de Medicina y Zootecnia de Cerdos, Facultad de Medicina Veterinaria y Zootecnia , Universidad Nacional Autónoma de México , Ciudad de México , México

3. Endocrine Research Unit , UMAE Hospital de Especialidades, Instituto Mexicano del Seguro Social , Ciudad de México , México

4. Cardiology Department , Hospital General Regional Lic Ignacio Garcia Tellez IMSS , Mérida , Yucatán , México

5. Escuela Nacional de Estudios Superiores, Licenciatura en Optometría, Unidad León, Universidad Nacional Autónoma de México , Ciudad de México , México

6. Tecnológico Nacional de México/ ITOaxaca , Oaxaca , México

7. Research Centre Medicine UNAM-UABJO. Facultad de Medicina , Universidad Autónoma “Benito Juárez” de Oaxaca , Oaxaca , México

8. Unidad de Investigación en Reproducción Humana. Instituto Nacional de Perinatología-Facultad de Química , Universidad Nacional Autónoma de México , Ciudad de México , México

Abstract

Abstract Objectives Patients with type 1 diabetes mellitus have been reported to have elevated prolactin levels and a possible relationship between prolactin levels and the development of the disease has been proposed. However, some studies show that prolactin mediates beneficial functions in beta cells. Therefore, we review information on the roles of prolactin in type 1 diabetes mellitus. Content Here we summarize the functions of prolactin in the immune system and in pancreatic beta cells, in addition, we describe studies related to PRL levels, its regulation and alterations of secretion in patients with type 1 diabetes mellitus. Summary Studies in murine models have shown that prolactin protects beta cells from apoptosis, stimulates their proliferation and promotes pancreatic islet revascularization. In addition, some studies in patients with type 1 diabetes mellitus have shown that elevated prolactin levels correlate with better disease control. Outlook Prolactin treatment appears to be a promising strategy to improve beta-cell vascularization and proliferation in transplantation and immunotherapies.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism

Link

https://www.degruyter.com/document/doi/10.1515/hmbci-2022-0008/pdf

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