Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects
Author:
Alizadeh Farhad12, Mirzaie Bavil Fariba32, Keyhanmanesh Rana32ORCID, Lotfi Hajie45, Ghiasi Fariba62
Affiliation:
1. Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran 2. Department of Physiology, Faculty of Medicine , Tabriz University of Medical Sciences , Tabriz , Iran 3. Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran 4. Cellular and Molecular Research Center , Research Institute for prevention of Non-Communicable Disease, Qazvin University of Medical Sciences , Qazvin , Iran 5. Student Research Committee , Qazvin University of Medical Sciences , Qazvin , Iran 6. Stem Cell Research Center , Tabriz University of Medical Sciences , Tabriz , Iran
Abstract
Abstract
Objectives
Investigation the association of pro-inflammatory markers interleukin (IL)-1β and IL- 10 expression, serum levels of C-reactive protein (CRP), cyclooxygenase-2 (COX2), High-density lipoprotein (HDL), Apolipoprotein A1 (ApoA1), and ATP Binding Cassette Subfamily A Member 1 (ABCA1) inflammatory proteins with atherosclerosis index (homocysteine) in normal-weight and obese male subjects.
Methods
59 males including 30 obese (Body mass index (BMI) of ≥30 kg/m2) and 29 normal-weight (BMI of 18.5–24.9 kg/m2) were joined to this study. Plasma levels of IL-1β and IL-10 (pg/mL), CRP (pg/mL), COX-2 (ng/mL), APOA1 (mg/dL), ABCA1 (ng/mL), HDL, Cholesterol, and Triglyceride (TG) (mg/dL), and homocysteine (µmol/L) was measured. Association of these biomarkers with homocysteine was determined.
Results
Obese subjects had higher serum levels of IL10, IL1β, CRP, COX-2, TG, and cholesterol concentrations (all p<0.05 except IL-10 and cholesterol) and low levels of HDL, APOA1, and ABCA1 (non-significant differences) in comparison to normal-weight group. Homocysteine levels were high in obese men with no significant differences between the two groups. In obese subjects, homocysteine had a significant inverse correlation with APOA1, ABCA1, and HDL, and a strong and moderate positive correlation was found with CRP and TG levels, respectively.
Conclusions
High level of homocysteine and its correlation with inflammation proteins and markers in obese subjects appear to be contributed with atherosclerosis development.
Funder
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
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