Two new polyacetylene derivatives from the Red Sea sponge Xestospongia sp.-Reference-Cited by-同舟云学术

Two new polyacetylene derivatives from the Red Sea sponge Xestospongia sp.

Published:2015-11-01 Issue:11-12 Volume:70 Page:297-303
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Ayyad Seif-Eldin N.,Katoua Dina F.¹,Alarif Walied M.²,Sobahi Tariq R.¹,Aly Magda M.³,Shaala Lamiaa A.⁴,Ghandourah Mohamed A.²

Affiliation:

1. Faculty of Science, Department of Chemistry, King Abdulaziz University, P.O. 80203, Jeddah 21589, KSA

2. Faculty of Marine Sciences, Department of Marine Cchemistry, King Abdulaziz University, P.O. 80207, Jeddah 21589, KSA

3. Faculty of Science, Bioloy Department, King Abdulaziz University, P.O. 80203, Jeddah 21589, KSA

4. Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, KSA

Abstract

Abstract Two new polyacetylenes (1 and 2), along with two known C-30 steroids (3 and 4) were identified from the Red Sea sponge, Xestospongia sp. The chemical structures were determined based on extensive spectroscopic measurements 1D (1H, 13C and DEPT) and 2D (COSY, HSQC and HMBC) NMR, UV, IR and MS. The new compounds 1 and 2 were evaluated for their antimicrobial and antitumor activities. 1 and 2 were active against multidrug- resistant bacteria with MICs ranged from 2.2 to 4.5 μM. No toxicity was recorded for the two tested compounds up to 5 μM using Artemia salina as a test organism. Compound 2 showed excellent antifungal activity against some pathogenic fungi such as Aspergillus niger and Candida albicans (MIC 2.2–2.5 μM) and antitumor activity against both Ehrlich ascites carcinoma and lymphocytic leukemia (LD50 5.0 μM).

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2015-5015/pdf

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