Redox-dependent and independent effects of thioredoxin interacting protein-Reference-Cited by-同舟云学术

Redox-dependent and independent effects of thioredoxin interacting protein

Published:2020-10-25 Issue:11 Volume:401 Page:1215-1231
ISSN:1437-4315
Container-title:Biological Chemistry
language:
Short-container-title:

Author:

Cao Xiankun¹,He Wenxin¹,Pang Yichuan²,Cao Yu³,Qin An¹

Affiliation:

1. Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, People’s Republic of China

2. Department of Oral Surgery, Shanghai Key Laboratory of Stomatology, National Clinical Research Center of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of China

3. Department of Orthopaedics and Institute of Precision Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, People’s Republic of China

Abstract

AbstractThioredoxin interacting protein (TXNIP) is an important physiological inhibitor of the thioredoxin (TXN) redox system in cells. Regulation of TXNIP expression and/or activity not only plays an important role in redox regulation but also exerts redox-independent physiological effects that exhibit direct pathophysiological consequences including elevated inflammatory response, aberrant glucose metabolism, cellular senescence and apoptosis, cellular immunity, and tumorigenesis. This review provides a brief overview of the current knowledge concerning the redox-dependent and independent roles of TXNIP and its relevance to various disease states. The implications for the therapeutic targeting of TXNIP will also be discussed.

Funder

National Infrastructures for Translational Medicine (Shanghai) opening topic

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/downloadpdf/journals/bchm/401/11/article-p1215.xml

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