Bioguided isolation of antiplasmodial secondary metabolites from Persea americana Mill. (Lauraceae)-Reference-Cited by-同舟云学术

Bioguided isolation of antiplasmodial secondary metabolites from Persea americana Mill. (Lauraceae)

Published:2021-11-18 Issue:0 Volume:0 Page:
ISSN:0939-5075
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Waleguele Christine Claire¹²,Tchuente Tchuenmogne Marthe Aimée³,Fotsing Fongang Yannick Stéphane⁴,Ngatchou Jules¹,Kezetas Bankeu Jean Jules⁵^ORCID,Ngouela Augustin Silvère¹,Tsamo Etienne¹,Sewald Norbert⁶^ORCID,Krause Rui Werner Maçedo²^ORCID,Lenta Bruno Ndjakou⁷

Affiliation:

1. Department of Organic Chemistry , Faculty of Science, University of Yaoundé I , P.O. Box 812 , Yaoundé , Cameroon

2. Department of Chemistry , Rhodes University , P.O. Box 94 , Grahamstown/Makhanda 6140 , South Africa

3. Department of Chemistry , Faculty of Science, University of Dschang , P.O. Box 67 , Dschang , Cameroon

4. Department of Chemistry , Higher Teachers’ Training College, University of Maroua , P.O. Box 55 , Maroua , Cameroon

5. Department of Chemistry , Faculty of Science, The University of Bamenda , P.O. Box 39 , Bambili , Cameroon

6. Department of Chemistry , Bielefeld University , P.O. Box 100131, 33501 Bielefeld , Germany

7. Department of Chemistry , Higher Teacher Training College, University of Yaoundé I , P.O. Box 47 , Yaoundé , Cameroon

Abstract

Abstract The antiplasmodium assay-guided investigation of the roots, stem bark, and leaves of Persea americana Mill. led to the isolation of a new fatty alcohol, perseatriol (1), along with six known compounds (2–7). Their structures were elucidated based on the analysis of their NMR and MS data. All crude extracts and fractions exhibited good antiplasmodial activity on Plasmoduim falciparum 3D7 with IC50 values ranging from 0.76 to 10.5 μg/mL; they also displayed cytotoxicity against HeLa cells with low selectivity indexes (SIs). A preliminary Plasmodium lactate dehydrogenase (pLDH) assay was also performed on the isolated compounds. 9,9′-Di-O-feruloyl-5,5′-dimethoxysecoisolariciresinol (4) turned out to be non-toxic and displayed the best activities on P. falciparum with an IC50 value of 0.05 μM, comparable to the reference drug chloroquine with an IC50 value of 0.03 μM. Furthermore, besides compound 4, this work reports the first isolation of lutein (2) and scopoletin (3) from P. americana. The crude extracts of roots, stem bark, and leaves of P. americana, their fractions and compounds completely suppressed the growth of P. falciparum. The observed activity supports the use of P. americana in folk medicine for the treatment of malaria.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2021-0182/pdf

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