Affiliation:
1. Department of Advanced Nuclear Medicine Sciences , Institute for Quantum Medical Sciences (iQMS), National Institutes for Quantum Science and Technology (QST) , 4-9-1 Anagawa, Inage , Chiba 263-8555 , Japan
Abstract
Abstract
Rhodium-103m is one of the most attractive Auger electron emitters for internal radiotherapy. The half-life of 103mRh is relatively short (56.114 min). Therefore, it needs to be produced using a generator for clinical use. Most studies of 103Pd/103mRh generators using anion-exchange resins were carried out over 50 years ago. However, these resins are no longer commercially available. In the present study, we tested a 103Pd/103mRh generator using alternative anion-exchange resins (i.e., IRA904, IRA410, SA20A, and SA11AL). No-carrier-added 103Pd was used to make the generators. The 103mRh product was eluted from the generators using 6 mL of 0.1 M HCl with a flow rate 0.5 mL/min. The generator made from SA11AL showed good performance, with a yield of 39 %, an impurity level of 103Pd in the product of 0.29 %, and an operation time of 14 min. This makes this generator competitive with previously developed ones.
Subject
Physical and Theoretical Chemistry
Reference27 articles.
1. Cole, A. Absorption of 20-eV to 50,000-eV electron beams in air and plastic. Radiat. Res. 1969, 38, 7; https://doi.org/10.2307/3572707.
2. Kassis, A. I., Adelstein, S. J. Radiobiologic principles in radionuclide therapy. J. Nucl. Med. 2005, 46, 4S.
3. Bernhardt, P., Forssell-Aronsson, E., Jacobsson, L., Skarnemark, G. Low-energy electron emitters for targeted radiotherapy of small tumors. Acta Oncol. 2001, 40, 602; https://doi.org/10.1080/028418601750444141.
4. Filosofov, D., Kurakina, E., Radchenko, V. Potent candidates for targeted Auger therapy: production and radiochemical considerations. Nucl. Med. Biol. 2021, 94–95, 1; https://doi.org/10.1016/j.nucmedbio.2020.12.001.
5. National Nuclear Data Center. NuDat 3.0; Brookhaven National Laboratory: NY. https://www.nndc.bnl.gov/nudat3/.