Applications of DNA tetrahedron nanostructure in cancer diagnosis and anticancer drugs delivery-Reference-Cited by-同舟云学术

Applications of DNA tetrahedron nanostructure in cancer diagnosis and anticancer drugs delivery

Published:2023-01-01 Issue:1 Volume:12 Page:
ISSN:2191-9097
Container-title:Nanotechnology Reviews
language:en
Short-container-title:

Author:

Long Qipeng¹,Tian Xinchen¹²,Wang Haochen¹,Zhang Ni¹²,Han Tao³,Li Zhe⁴⁵,Jiang Shulong¹

Affiliation:

1. Clinical Medical Laboratory Center, Jining First People’s Hospital, Shandong First Medical University , Jining , Shandong 272000 , China

2. Cheeloo College of Medicine, Shandong University , Jinan , Shandong 250100 , China

3. Institutes of Health Central Plains, Xinxiang Medical University , Xinxiang 453003 , China

4. Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University , Nanjing 210023 , China

5. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 , China

Abstract

Abstract DNA nanostructures constructed under the guidance of DNA nanotechnology have developed rapidly for the last two decades, standing at the forefront in the biomedical field. Among them, DNA tetrahedron nanostructure (DTN) has emerged as one of the most representative DNA nanostructures. DTN was easily formed by one-step annealing of four single-stranded DNA. Due to its unique advantages such as simple and stable structural composition, high synthesis efficiency, uniform nanometer size, high programmability, and good biocompatibility, DTN has been widely used in biological detection, biological imaging, drug delivery, and other fields, and shows a great potential. Especially in the detection of cancer-related biomarkers and the delivery of anticancer drugs, nano-platforms based on DTN has achieved great success. In this review, we focus on the applications of DTN in cancer diagnosis and therapy, as well as the challenges and prospects.

Publisher

Walter de Gruyter GmbH

Subject

Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology

Link

https://www.degruyter.com/document/doi/10.1515/ntrev-2022-0553/pdf

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