Development of graphene and graphene quantum dots toward biomedical engineering applications: A review

Author:

Handayani Murni1,Hendrik 2,Abbas Aumber3,Anshori Isa4,Mulyawan Rahmat4,Satriawan Ardianto4,Shalannanda Wervyan4,Setianingsih Casi5,Pingak Charline Tiara Rehuellah6,Zahro Qurriyatus6,Rurisa Ayu Candra Sekar6,Setiawan Iwan6,Khotimah Khusnul1,Sunnardianto Gagus Ketut789,Rahmayanti Yosephin Dewiani1

Affiliation:

1. Research Centre for Advanced Material, National Research and Innovation Agency (BRIN) , Tangerang Selatan , 15314 , Indonesia

2. Research Centre for Metallurgy, National Research and Innovation Agency (BRIN) , Tangerang Selatan , 15314 , Indonesia

3. School of Engineering, Newcastle University , Newcastle Upon Tyne , NE1 7RU , United Kingdom

4. School of Electrical Engineering and Informatics, Bandung Institute of Technology , Bandung , 40132 , Indonesia

5. Department of Computer Engineering, School of Electrical Engineering, Telkom University , Bandung , Indonesia

6. Mechanical Engineering Department, Faculty of Engineering and Technology, Sampoerna University , Jakarta , 12780 , Indonesia

7. School of Materials Science and Engineering, Nanyang Technological University , 50 Nanyang Avenue , Singapore , 639798 , Singapore

8. Research Center for Quantum Physics, National Research and Innovation Agency (BRIN) , Tangerang Selatan , Indonesia

9. Research Collaboration Center for Quantum Technology 2.0 , Bandung , 40132 , Indonesia

Abstract

Abstract Research on the application of graphene (G) and graphene quantum dots (GQDs) for biomedical engineering has attracted much attention over the last decade. Graphene and its derivatives have shown great biocompatibility, solubility, selectivity, large surface area, high purity, biofunctionalization, high drug loading capacity, and cell membrane penetration capability potential to be applied in biomedical engineering areas. The unique physical and chemical properties of GQDs, including small size, chemical inertness, high photoluminescence stability, low cytotoxicity, and good biocompatibility, made them a promising candidate for biomedical engineering applications. The recent progress related to the development of G and GQDs toward biomedical engineering applications is presented in this work. This study reviews and discusses the development of G and GQDs, both top-down and bottom-up synthesis methods, for biomedical engineering applications, such as biosensing, tissue engineering, drug delivery, bioimaging, antibacterial, and antiviral.

Publisher

Walter de Gruyter GmbH

Subject

Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology

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