Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

Author:

Xing Fei1,Zhou Changchun23,Hui Didi4,Du Colin4,Wu Lina23,Wang Linnan1,Wang Wenzhao1,Pu Xiaobing5,Gu Linxia6,Liu Lei1,Xiang Zhou1,Zhang Xingdong23

Affiliation:

1. Department of Orthopaedics, West China Hospital, Sichuan University , 610041 , Chengdu , China

2. National Engineering Research Center for Biomaterials, Sichuan University , 610064 , Chengdu , China

3. College of Biomedical Engineering, Sichuan University , 610064 , Chengdu , China

4. Innovatus Oral Cosmetic & Surgical Institute , Norman , OK, 73069 , United States of America

5. Department of Orthopedics Medical Center, West China School of Public Health and West China Fourth Hospital, Sichuan University , Chengdu , Sichuan , China

6. Department of Biomedical and Chemical Engineering and Sciences, College of Engineering & Science, Florida Institute of Technology , Melbourne , FL, 32901 , United States of America

Abstract

Abstract Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.

Publisher

Walter de Gruyter GmbH

Subject

Surfaces, Coatings and Films,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomaterials,Medicine (miscellaneous),Biotechnology

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