Affiliation:
1. Department of Medical Physiology , 68787 Medical Research and Clinical Studies Institute, National Research Centre , Dokki , Cairo , Egypt
2. Department of Pharmacology , 68787 Medical Research and Clinical Studies Institute, National Research Centre , Dokki , Cairo , Egypt
Abstract
Abstract
Background
Favism is a metabolic disease and this study evaluates the effectiveness of palm oil and its triacylglycerol constituent in favism-induced female rats to restore serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation.
Methods
Animals were 36 female albino rats. They classified to two equal (normal and favism) groups. The normal group was divided into three equal subgroups: the control, palm oil, and triacylglycerol subgroups. The normal rats were given 1 mL of saline, 1 mL of palm oil, and 1 mL of triacylglycerol orally, respectively. The Favism group was classified also into three equal subgroups: the favism group, the favism + palm oil, the Favism + triacylglycerol. The favism rats were given 1 mL of saline, 1 mL of palm oil, and 1 mL of triacylglycerol orally. For four weeks, all treatments were administered orally via oral gavage once daily.
Results
The hemoglobin, hematocrite, the blood cells, glucose and glucose-6-phosphate dehydrogenase, and liver function were decreased in favism. Female hormones such as serum luteinizing hormone, follicle stimulating hormone, Estrone, Estriol, 17α-Estradiol, 17β-Estradiol, and Estradiol-17-β-stearate were decreased in favism. Ovarian antioxidants were decreased while ovarian inflammatory markers were increased in favism. Favism induced ovarian DNA apoptosis. Furthermore, oral administration with palm oil or its triacylglycerol constituent in favism-induced female rats restored all these parameters to be approached the control levels.
Conclusions
Palm oil restored serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats and this effect related to oil triacylglycerol constituent.
Reference50 articles.
1. McMillan, DC, Jollow, DJ. Favism: divicine hemotoxicity in the rat. Toxicol Sci 1999;51:310–16. https://doi.org/10.1093/toxsci/51.2.310.
2. Bicakci, Z. A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (Vetch). Saudi Med J 2009;30:292–4.
3. Arese, P, Mannuzzu, L, Turrini, F. Pathophysiology of favism. Folia Haematol 1989;116:745–52.
4. Albano, E, Tomasi, A, Mannuzzu, L, Arese, P. Detection of free radical intermediate from divicine of Vicia faba. Biochem Pharmacol 1984;33:1701–4. https://doi.org/10.1016/0006-2952(84)90299-5.
5. Marquardt, RR. Vicine, Convicine and their role aglycnes-divine and isouramil. In: Cheeke, P, editor. Toxicants of plant origin, 2nd ed. Boca Raton, F. l., New York, USA: CRC Press; 1989:614–23 pp.
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