The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal

Author:

Schirinzi Tommaso1,Canevelli Marco23,Suppa Antonio24,Bologna Matteo24,Marsili Luca5ORCID

Affiliation:

1. Department of Systems Medicine , University of Rome Tor Vergata , Rome , Italy

2. Department of Human Neurosciences , Sapienza University of Rome , Rome , Italy

3. National Center for Disease Prevention and Health Promotion, National Institute of Health , Rome , Italy

4. IRCCS Neuromed , Pozzilli , IS , Italy

5. Department of Neurology, Gardner Family Center for Parkinson’s Disease and Movement Disorders , University of Cincinnati , 260 Stetson Street , Cincinnati , 45219, OH , USA

Abstract

Abstract While the “physiological” aging process is associated with declines in motor and cognitive features, these changes do not significantly impair functions and activities of daily living. Differently, motor and cognitive impairment constitute the most common phenotypic expressions of neurodegeneration. Both manifestations frequently coexist in the same disease, thus making difficult to detect “pure” motor or cognitive conditions. Movement disorders are often characterized by cognitive disturbances, and neurodegenerative dementias often exhibit the occurrence of movement disorders. Such a phenotypic overlap suggests approaching these conditions by highlighting the commonalities of entities traditionally considered distinct. In the present review, we critically reappraised the common clinical and pathophysiological aspects of neurodegeneration in both animal models and patients, looking at motricity as a trait d’union over the spectrum of neurodegeneration and focusing on synaptopathy and oscillopathy as the common pathogenic background. Finally, we discussed the possible role of movement as neuroprotective intervention in neurodegenerative conditions, regardless of the etiology. The identification of commonalities is critical to drive future research and develop novel possible disease-modifying interventions.

Funder

Italian Ministry of Health

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Reference187 articles.

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