Affiliation:
1. Institute of Cellular Biochemistry, University Medicine , Humboldtallee 23, D-37073 Göttingen , Germany
Abstract
Abstract
Atg18, Atg21 and Hsv2 are homologous β-propeller proteins binding to PI3P and PI(3,5)P2. Atg18 is thought to organize lipid transferring protein complexes at contact sites of the growing autophagosome (phagophore) with both the ER and the vacuole. Atg21 is restricted to the vacuole phagophore contact, where it organizes part of the Atg8-lipidation machinery. The role of Hsv2 is less understood, it partly affects micronucleophagy. Atg18 is further involved in regulation of PI(3,5)P2 synthesis. Recently, a novel Atg18-retromer complex and its role in vacuole homeostasis and membrane fission was uncovered.
Funder
Deutsche Forschungsgemeinschaft
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Cited by
3 articles.
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