The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression-Reference-Cited by-同舟云学术

The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression

Published:2023-07-01 Issue:8-9 Volume:404 Page:845-850
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Querl Luisa¹,Krebber Heike¹^ORCID

Affiliation:

1. Abteilung für Molekulare Genetik , Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen , Grisebachstr. 8, D-37077 Göttingen , Germany

Abstract

Abstract Cell viability largely depends on the surveillance of mRNA export and translation. Upon pre-mRNA processing and nuclear quality control, mature mRNAs are exported into the cytoplasm via Mex67-Mtr2 attachment. At the cytoplasmic site of the nuclear pore complex, the export receptor is displaced by the action of the DEAD-box RNA helicase Dbp5. Subsequent quality control of the open reading frame requires translation. Our studies suggest an involvement of Dbp5 in cytoplasmic no-go-and non-stop decay. Most importantly, we have also identified a key function for Dbp5 in translation termination, which identifies this helicase as a master regulator of mRNA expression.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2023-0130/pdf

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