Role of Epstein-Barr virus in the development of nasopharyngeal carcinoma

Author:

Zhang Hui1,Wang Jing1,Yu Dan1,Liu Yan1,Xue Kai1,Zhao Xue1

Affiliation:

1. Department of Otolaryngology Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130041, China

Abstract

AbstractSouthern China experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated. The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The pathophysiology in making of EBV into a cancerogen includes proteins as latent membrane protein 1 (LMPs) and nucleic acids as micro-RNAs. In this paper, we reviewed till date studies focusing on relationship between EBV and nasopharyngeal carcinoma.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

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