Peripheral mechanisms of chronic pain-Reference-Cited by-同舟云学术

Peripheral mechanisms of chronic pain

Published:2022-06-01 Issue:3 Volume:2 Page:251-270
ISSN:2749-9642
Container-title:Medical Review
language:en
Short-container-title:

Author:

Zheng Qin¹,Dong Xintong²,Green Dustin P.³,Dong Xinzhong²⁴^ORCID

Affiliation:

1. Department of Anesthesiology and Critical Care Medicine, School of Medicine , Johns Hopkins University , Baltimore , MD , USA

2. The Solomon H. Snyder Department of Neuroscience, School of Medicine , Johns Hopkins University , Baltimore , MD , USA

3. Department of Neuroscience, Cell Biology, and Anatomy , University of Texas Medical Branch , Galveston , TX , USA

4. Howard Hughes Medical Institute, School of Medicine , Johns Hopkins University , Baltimore , MD , USA

Abstract

Abstract Acutely, pain serves to protect us from potentially harmful stimuli, however damage to the somatosensory system can cause maladaptive changes in neurons leading to chronic pain. Although acute pain is fairly well controlled, chronic pain remains difficult to treat. Chronic pain is primarily a neuropathic condition, but studies examining the mechanisms underlying chronic pain are now looking beyond afferent nerve lesions and exploring new receptor targets, immune cells, and the role of the autonomic nervous system in contributing chronic pain conditions. The studies outlined in this review reveal how chronic pain is not only confined to alterations in the nervous system and presents findings on new treatment targets and for this debilitating disease.

Funder

Howard Hughes Medical Institute

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/mr-2022-0013/pdf

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