Gender-related differences in cardiometabolic risk factors and oxidative stress among prepubertal children with obesity-Reference-Cited by-同舟云学术

Gender-related differences in cardiometabolic risk factors and oxidative stress among prepubertal children with obesity

Published:2023-12-07 Issue:1 Volume:37 Page:42-51
ISSN:0334-018X
Container-title:Journal of Pediatric Endocrinology and Metabolism
language:en
Short-container-title:

Author:

Godinho Nelson¹^ORCID,Morato Manuela²³,Albino-Teixeira António⁴⁵,Caldas Afonso Alberto¹⁶⁷⁸,Sousa Teresa⁴⁵,Correia-Costa Liane¹⁶⁷⁸

Affiliation:

1. Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Porto , Portugal

2. Laboratório de Farmacologia, Departamento de Ciências do Medicamento, Faculdade de Farmácia , Universidade do Porto (FFUP) , Porto , Portugal

3. LAQV/REQUIMTE, Faculdade de Farmácia , Universidade do Porto , Porto , Portugal

4. Departamento de Biomedicina – Unidade de Farmacologia e Terapêutica, Faculdade de Medicina , Universidade do Porto , Porto , Portugal

5. MedInUP – Centro de Investigação Farmacológica e Inovação Medicamentosa da Universidade do Porto , Porto , Portugal

6. EPIUnit – Instituto de Saúde Pública, Universidade do Porto , Porto , Portugal

7. Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR) , Universidade do Porto , Porto , Portugal

8. Unidade de Nefrologia Pediátrica, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário de Santo António , Porto , Portugal

Abstract

Abstract Objectives Gender-related differences in oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors were examined in a cross-sectional study involving 313 prepubertal children (8–9 years old) from the generation XXI birth-cohort. Methods Anthropometric measurements, cardiometabolic variables, and redox markers were assessed, including plasma and urinary isoprostanes (P-Isop, U-Isop), plasma total antioxidant status (P-TAS), serum myeloperoxidase (MPO), plasma and urinary nitrates and nitrites (P-NOX, U-NOX), and urinary hydrogen peroxide (U-H2O2). Results Girls showed higher levels of total/non-HDL cholesterol, triglycerides, and insulin resistance (HOMA-IR) compared to boys. Notably, U-H2O2 values were lower in girls. When stratifying by body mass index (BMI) and gender, both girls and boys exhibited higher MPO concentration and U-Isop values. Uric acid concentration was higher in overweight and obese girls than in normal weight girls, while no significant differences were observed among boys across BMI categories. Furthermore, U-NOX values differed only in boys, with higher levels observed in overweight and obese individuals compared to those with normal weight. Multivariate analysis, adjusted for age and BMI z-score, demonstrated inverse associations between U-H2O2 and pulse wave velocity values, as well as between U-NOX and total or non-HDL cholesterol, exclusively in boys. In girls, a positive association between U-Isop and HOMA-IR values was observed. Conclusions In conclusion, gender differentially impacts oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors in prepubertal children. Prepubertal girls appear more susceptible to oxidative stress-induced metabolic dysfunction, while in boys, elevated levels of redox and nitric oxide bioavailability markers seem to provide protection against arterial stiffness and lipid homeostasis.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpem-2023-0286/pdf

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