Anti-Leishmania activity of extracts from Piper cabralanum C.DC. (Piperaceae)-Reference-Cited by-同舟云学术

Anti-Leishmania activity of extracts from Piper cabralanum C.DC. (Piperaceae)

Published:2021-03-02 Issue:5-6 Volume:76 Page:229-241
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Valéria Amorim Layane¹,de Lima Moreira Davyson²,Muálem de Moraes Alves Michel¹,Jessé Ramos Ygor²,Pereira Costa Sobrinho Enoque¹,Arcanjo Daniel Dias Rufino³^ORCID,Rodrigues de Araújo Alyne⁴,de Souza de Almeida Leite José Roberto⁵^ORCID,das Chagas Pereira de Andrade Francisco⁶,Mendes Anderson Nogueira⁶^ORCID,Aécio de Amorim Carvalho Fernando¹

Affiliation:

1. Antileishmania Activity Laboratory , Federal University of Piauí , Teresina , Piauí , Brazil

2. Natural Products Laboratory , Institute of Pharmaceutical Tecnologies, Farmanguinhos, Oswaldo Cruz Foundation , Rio de Janeiro-RJ , Brazil

3. Department of Biophysics and Physiology, Laboratory of Funcional and Molecular Studies in Physiopharmacology , Federal University of Piauí , Teresina , Piauí , Brazil

4. Research Center on Biodiversity and Biotechnology , BIOTEC, Federal University of Delta of Parnaíba, UFDPar , Parnaíba , Piauí , Brazil

5. Center for Research in Applied Morphology and Immunology , NuPMIA, University of Brasilia , Brasilia , Brazil

6. Department of Biophysics and Physiology, Laboratory of Innovation on Science and Technology , Federal University of Piauí , Teresina , Piauí , Brazil

Abstract

Abstract Species of Piperaceae are known by biological properties, including antiparasitic such as leishmanicidal, antimalarial and in the treatment of schistosomiasis. The aim of this work was to evaluate the antileishmania activity, cytotoxic effect, and macrophage activation patterns of the methanol (MeOH), hexane (HEX), dichloromethane (DCM) and ethyl acetate (EtOAc) extract fractions from the leaves of Piper cabralanum C.DC. The MeOH, HEX and DCM fractions inhibited Leishmanina amazonensis promastigote-like forms growth with a half maximal inhibitory concentration (IC50) of 144.54, 59.92, and 64.87 μg/mL, respectively. The EtOAc fraction did not show any relevant activity. The half maximal cytotoxic concentration (CC50) for macrophages were determined as 370.70, 83.99, 113.68 and 607 μg/mL for the MeOH, HEX and DCM fractions, respectively. The macrophage infectivity was concentration-dependent, especially for HEX and DCM. MeOH, HEX and DCM fractions showed activity against L. amazonensis with low cytotoxicity to murine macrophages and lowering infectivity by the parasite. Our results provide support for in vivo studies related to a potential application of P. cabralanum extract and fractions as a promising natural resource in the treatment of leishmaniasis.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2020-0284/pdf

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