A review on pulmonary and mediastinal synovial sarcoma
Author:
Dewi Kristin Purnama12ORCID, Dewi Ivana Purnama32ORCID, Iswanto Iswanto2ORCID, Wulandari Laksmi1ORCID
Affiliation:
1. Department of Pulmonology and Respiratory Medicine , Faculty of Medicine , Airlangga University - Dr. Soetomo General Hospital , Surabaya , Indonesia 2. Faculty of Medicine , Duta Wacana Christian University , Yogyakarta , Indonesia 3. Department of Cardiology and Vascular , Faculty of Medicine , Airlangga University - Dr. Soetomo General Hospital , Surabaya , Indonesia
Abstract
Abstract
Sarcoma is defined as a tumor located in the thoracic cavity. However, sarcoma can occur on every side of the body. Synovial sarcoma is a rare soft tissue tumor originating from pluripotent with a high malignancy rate. The most common predilection of synovial sarcoma is in the joints. Primary synovial sarcoma of the lung and mediastinum are rare tumors and generally malignant. There are only a few cases have been reported. Definite diagnosis is made by histopathological, immunohistochemistry, and cytogenetic examination. The management strategy for synovial sarcoma requires multimodality treatment with surgery, chemotherapy, and radiotherapy. However, effective and relatively non-toxic therapy for primary synovial sarcoma is still developed. The five years life expectancy is higher if the patient received adjuvant radiotherapy and/or chemotherapy after surgery.
Publisher
Walter de Gruyter GmbH
Subject
Drug Discovery,Pharmacology,General Medicine,Physiology
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