A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage-Reference-Cited by-同舟云学术

A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage

Published:2022-11-02 Issue:22 Volume:11 Page:5133-5142
ISSN:2192-8606
Container-title:Nanophotonics
language:en
Short-container-title:

Author:

Gong Xiyu¹,Fan Xingyu²,He Yongju²,Wang Yingwei³,Zhou Fangfang¹,Yang Binbin¹^ORCID

Affiliation:

1. Department of neurology , The Second Xiangya Hospital, Central South University , Changsha , Hunan 410011 , China

2. School of Materials Science and Engineering , Central South University , Changsha , Hunan 410083 , China

3. Hunan Key Laboratory of Nanophotonics and Divices , Central South University , Changsha , Hunan 410083 , China

Abstract

Abstract Intracerebral hemorrhage (ICH) is one of the most devastating types of stroke. This study aims to develop a new drug carrier with hematoma-specific response and high property. pH-sensitive liposomes (PSL) were developed. Fingolimod with ammonia borane were encapsulated in the phospholipid vesicles to integrate two drugs for treating ICH more effectively. pH sensitive PSL-FTY720/AB was characterized for various physicochemical parameters such as shape, surface morphology, vesicle size, zeta-potential, in-vitro drug release in different pH environment, cellular toxicity, in-vivo and ex-vivo tissue accumulation. In vivo results further confirmed that drug-loading nanoparticles effectively protected against ICH-induced brain injury through synergistic effect of anti-inflammation and anti-oxidation. Collectively, the present study confirmed that PSL-FTY720/AB can be an effective, safe, and a novel alternative treatment approach in ICH.

Publisher

Walter de Gruyter GmbH

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials,Biotechnology

Link

https://www.degruyter.com/document/doi/10.1515/nanoph-2022-0496/pdf

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