A morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide induces ferroptosis in tumor cells by targeting NRF2
Author:
Affiliation:
1. First Affiliated Hospital of Jinan University
2. School of Medicine, Foshan University
3. Department of Obstetrics and Gynecology of Affiliated Hospital, the Marine Biomedical Research Institute, Guangdong Medical University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/advpub/0/advpub_b23-00544/_pdf
Reference32 articles.
1. 1) Kourounakis AP, Xanthopoulos D, Tzara A: Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules. Med Res Rev, 40, 709-752 (2020).
2. 2) Song Z, Huang S, Yu H, Jiang Y, Wang C, Meng Q, Shu X, Sun H, Liu K, Li Y, Ma X: Synthesis and biological evaluation of morpholine-substituted diphenylpyrimidine derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors with improved activity toward the gefitinib-resistant non-small cell lung cancers (NSCLC). Eur J Med Chem, 133, 329-339 (2017).
3. 3) Rahman FU, Ali A, Khan IU, Duong HQ, Yu SB, Lin YJ, Wang H, Li ZT, Zhang DW: Morpholine or methylpiperazine and salicylaldimine based heteroleptic square planner platinum (II) complexes: In vitro anticancer study and growth retardation effect on E. coli. Eur J Med Chem, 131, 263-274 (2017).
4. 4) Arshad F, Khan MF, Akhtar W, Alam MM, Nainwal LM, Kaushik SK, Akhter M, Parvez S, Hasan SM, Shaquiquzzaman M: Revealing quinquennial anticancer journey of morpholine: A SAR based review. Eur J Med Chem, 167, 324-356 (2019).
5. 5) Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, 3rd, Stockwell BR: Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 149, 1060-1072 (2012).
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