Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition
Author:
Affiliation:
1. Department of Biopharmacy, Faculty of Pharmacy, Srinakharinwirot University
2. Laboratory of Biochemistry, Chulabhorn Research Institute
3. Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/41/11/41_b18-00329/_pdf
Reference39 articles.
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2. 2) Karaman S, Detmar M. Mechanisms of lymphatic metastasis. J. Clin. Invest., 124, 922–928 (2014).
3. 3) Stacker SA, Achen MG. From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy. Lymphat. Res. Biol., 6, 165–172 (2008).
4. 4) Assimopoulou AN, Boskou D, Papageorgiou VP. Antioxidant activities of alkannin, shikonin and Alkanna tinctoria root extracts in oil substrates. Food Chem., 87, 433–438 (2004).
5. 5) Su L, Liu L, Wang Y, Yan G, Zhang Y. Long-term systemic toxicity of shikonin derivatives in Wistar rats. Pharm. Biol., 52, 486–490 (2014).
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