Investigation of Prescription Status and Exploration of Risk Factors Related to Denosumab-Induced Hypocalcemia in Combination Therapy with 1α,25-Dihydroxy-vitamin D<sub>3</sub>
Author:
Affiliation:
1. Division of Drug Informatics, Keio University Faculty of Pharmacy
2. Department of Pharmacy, Kameda General Hospital
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/46/1/46_b22-00649/_pdf
Reference15 articles.
1. 1) Kinoshita Y, Arai M, Ito N, Takashi Y, Makita N, Nangaku M, Shinoda Y, Fukumoto S. High serum ALP level is associated with increased risk of denosumab-related hypocalcemia in patients with bone metastases from solid tumors. Endocr. J., 63, 479–484 (2016).
2. 2) Kanbayashi Y, Sakaguchi K, Hongo F, Ishikawa T, Tabuchi Y, Ukimura O, Takayama K, Taguchi T. Predictors for development of denosumab-induced hypocalcaemia in cancer patients with bone metastases determined by ordered logistic regression analysis. Sci. Rep., 11, 978 (2021).
3. 3) Ikegami K, Hashiguchi M, Kizaki H, Yasumuro O, Funakoshi R, Hori S. Development of risk prediction model for grade 2 or higher hypocalcemia in patients with bone metastasis treated with denosumab plus cholecalciferol (vitamin D3)/calcium supplement. J. Clin. Pharmacol., 62, 1151–1159 (2022).
4. 4) Huynh AL, Baker ST, Stewardson AJ, Johnson DF. Denosumab-associated hypocalcaemia: incidence, severity and patient characteristics in a tertiary hospital setting. Pharmacoepidemiol. Drug Saf., 25, 1274–1278 (2016).
5. 5) Body JJ, Bone HG, de Boer RH, Stopeck A, Van Poznak C, Damião R, Fizazi K, Henry DH, Ibrahim T, Lipton A, Saad F, Shore N, Takano T, Shaywitz AJ, Wang H, Bracco OL, Braun A, Kostenuik PJ. Hypocalcaemia in patients with metastatic bone disease treated with denosumab. Eur. J. Cancer, 51, 1812–1821 (2015).
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