Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures
Author:
Affiliation:
1. Safety Research Laboratories, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation
2. Graduate School of Biomedical and Health Sciences, Hiroshima University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/41/5/41_b17-00913/_pdf
Reference37 articles.
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3. 3) Guengerich FP. Mechanisms of drug toxicity and relevance to pharmaceutical development. Drug Metab. Pharmacokinet., 26, 3–14 (2011).
4. 4) Guo L, Dial S, Shi L, Branham W, Liu J, Fang JL, Green B, Deng H, Kaput J, Ning B. Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes. Drug Metab. Dispos., 39, 528–538 (2011).
5. 5) Westerink WM, Schoonen WG. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro, 21, 1581–1591 (2007).
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