Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs
Author:
Affiliation:
1. Merck Research Laboratories, In Vitro Pharmacology, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Publisher
Informa Healthcare
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1517/17460441.2010.520700
Reference37 articles.
1. Drug–target residence time and its implications for lead optimization
2. Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function
3. The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety
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