HIV resistance testing in the USA – a model for the application of pharmacogenomics in the clinical setting

Author:

Blum Ronald A,Wylie Neil,England Tom,French Cynthia1

Affiliation:

1. Specialty Laboratories, 27027 Tourney Road, Valencia, CA 91355, USATel.: ;Fax: ;E-mail:

Abstract

Although there is debate about how and when the medical community will readily adopt pharmacogenomics into clinical practice, HIV genotyping has become an integral part of AIDS patient management in the USA since 1996. Genotyping for HIV-1 drug resistance serves as a paradigm for the way pharmacogenomics is likely to be introduced into patient care. This review discusses the unique role that HIV-1 genotype testing plays in identifying resistance in patients and how that information is used to modify therapy selection and impact the progression of disease [1] . In addition, the important issues relating to reimbursement and the cost-effectiveness of genotyping are also discussed.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pharmacogenomics of Viral Diseases;Omics for Personalized Medicine;2013

2. Homologous control of protein signaling networks;Journal of Theoretical Biology;2011-06

3. A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine;BMC Medical Informatics and Decision Making;2009-03-23

4. Clinical Decision Support in Genomic and Personalized Medicine;Genomic and Personalized Medicine;2009

5. The Drug Discovery Business to Come;Real World Drug Discovery;2008

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