Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

Author:

Adam Isabell1,Dewi Dyah L.1,Mooiweer Joram1ORCID,Sadik Ahmed1ORCID,Mohapatra Soumya R.1ORCID,Berdel Bianca1,Keil Melanie2,Sonner Jana K.2ORCID,Thedieck Kathrin34,Rose Adam J.5ORCID,Platten Michael26ORCID,Heiland Ines7ORCID,Trump Saskia8ORCID,Opitz Christiane A.19ORCID

Affiliation:

1. Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

2. DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany

3. Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signalling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

4. Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany

5. Nutrient Metabolism and Signalling Lab, Department of Biochemistry & Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia

6. Department of Neurology, University Hospital and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

7. Department of Arctic and Marine Biology, UiT Arctic University of Norway, Tromsø, Norway

8. Department of Environmental Immunology, Helmholtz Centre for Environmental Research, Leipzig, Germany

9. Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg, Heidelberg, Germany

Funder

BMBF

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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